Royal Air Force Typhoon jets have operated alongside French aircraft in a combined operation on an underground arms cache in Syria operated by the IS group, per a report from the UK's MoD.
The location, identified by reconnaissance, was believed to be housing weapons and explosive materials, the announcement noted, and was located in hills just above the historic site of Palmyra in the heart of Syria.
"Our aircraft utilized precision-guided Paveway IV munitions to strike a series of access tunnels down to the depot... initial indications are that the objective was successfully hit," the MoD said.
There was no sign of any civilian casualties in the strike late on Saturday and each participating jet made a safe return, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - referred to as Daesh - imposed extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This action underscores the UK's leading role, and commitment to stand shoulder to shoulder with allied nations, to eliminate any revival of Daesh and their dangerous and violent ideologies in the area," UK Defence Secretary John Healey said.
RAF aircraft have carried out patrols over Syria to "deter any attempted resurgence" of IS after its military defeat at the Baghuz confrontation in 2019, the MoD reported.
"I want to thank all the members of our armed forces involved in this strike for their skill and their bravery," he added. "They were among a great many British troops deployed over the holidays. This operation, to eliminate terrorist threats who pose a risk to our security, shows how British military are always on standby, continuously, protecting the UK within its borders and strong abroad."
During December, the American forces carried out what it termed a "large-scale strike" on Daesh sites in Syria, subsequent to an assault killed two US servicemembers and a civilian interpreter in Palmyra.
The UN estimates Daesh still has between 5,000 and 7,000 fighters in Iraq and Syria.
